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KMID : 0644120130260040014
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Journal of Oriental Gynecology
2013 Volume.26 No. 4 p.14 ~ p.29
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The Effect of Samul-tanggahyangbuja on Anti-Depressive Behavior and Immunity
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Jang Yoon-Jeong
Kim Song-Baek
Choi Chang-Min
Seo Yun-Jung
Cho Han-Baek
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Abstract
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Objectives: Samul-tang and Rhizome of Cyperus rotundus L. have been frequently used in gynecologic disease. The purpose of the present study is to explore the behavioral and neurobiological effects of Samul-tanggahyangbuja (SGH) on ovariectomized rats and to form a basis for clinical treatment.
Methods: Ovariectomized rats were repeatedly stressed for over 2 weeks. After orally medicated with SGH (200 or 400 mg/kg/day), the anxiety response was tested using the Elevated Plus Maze (EPM) in rats. The serum levels of estradiol and IL-4, and immunohistochemical changes of IL-4 in the Locus coeruleus (LC) and Paraventricular Nucleus (PVN) were measured.
Results:
1. In the EPM, SGH 400 mg significantly increased time spent on the open arms and decreased time spent on the closed arms, compared with the control group (p<0.05).
2. SGH tended to increase numbers of crossings in the open and closed arms in the EPM. However, it did not reach statistical significance.
3. SGH significantly increased the serum levels of estradiol compared with the control group (p<0.05).
4. SGH 400 mg significantly increased the serum levels of IL-4 compared with the control group (p<0.05).
5. IL-4 immunoreactivity was reduced in the control group compared with the normal group (p<0.05). However, SGH groups (200 and 400 mg) did not produce any significant effects on levels of IL-4 in the LC and PVN.
Conclusions: These results suggest that SGH possesses the anti-depressant and immuno-modulatory effects on ovariectomized rats.
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KEYWORD
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Menopausal Depression, Samul-tanggahyangbuja, Elevated Plus Maze (EPM), Estradiol, IL-4, Immunohistochemistry, Rhizome of Cyperus Rotundus L., Cyperi Rhizoma
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